Translational Bioinformatics

The course aims at presenting both algorithms and technologies for the analysis of biomedical data at the cellular and subcellular level (e.g. genomics and proteomics) and their translation into diagnostic, prognostic, and therapeutic applications in medicine. The course presents: a) the principles of molecular biology related to cell characteristics, DNA, RNA and gene analysis, focusing on the relation of biology with computer science, b) the basic techniques and algorithms for sequence comparison and statistical data processing, c) the basic IT infrastructure in which biological data is stored, with particular emphasis on online accessible databases along with the most important software tools used for their analysis (processing, cross-referencing, sharing and archiving of bioinformatics data, etc.), d) utility and limitations of public biomedical resources, e) issues and opportunities in drug discovery, and mobile/digital health solutions.